Optimal Testing for Diagnosis of Fructose Intolerance: Over-dosage Leads to False Positive Intolerance Test

Optimal Testing for Diagnosis of Fructose Intolerance: Over-dosage Leads to False Positive Intolerance Test

TO THE EDITOR: We read with interest the recent article by Goebel-Stengel et al and wish to express our appreciation and enthusiasm for their work on small intestinal bacterial overgrowth (SIBO) and carbohydrate intolerance in patients with irritable bowel syndrome (IBS). However, we have significant concerns regarding their methodology and basis for diagnosis of fructose intolerance. Goebel-St...

Optimal Testing for Diagnosis of Fructose Malabsorption: Under-dosage Leads to False Negative Intolerance Test

TO THE EDITOR: With great interest we have been following the discussion about our study published in Journal of Neurogastroenterology and Motility. 1 We highly estimate the recent constructive comments expressed by the authors Erdogan and colleagues 2 and would like to make some conclusive remarks. We fully agree with the authors that all patients with irritable bowel syndrome (IBS)-like sympt...

Fructose Intolerance.

Hereditary fructose intolerance.

Hereditary fructose intolerance (HFI, OMIM 22960), caused by catalytic deficiency of aldolase B (fructose-1,6-bisphosphate aldolase, EC 4.1.2.13), is a recessively inherited condition in which affected homozygotes develop hypoglycaemic and severe abdominal symptoms after taking foods containing fructose and cognate sugars. Continued ingestion of noxious sugars leads to hepatic and renal injury ...

Manifestation of hereditary fructose intolerance.

Death from P. falciparum infection in subjects who live in areas of stable malaria is usually due either to cerebral involvement or to the consequences of anaemia (Edington and Gilles, 1969). Almost all the data on increased resistance against malaria have been obtained in A/S heterozygotes, and there is no a priori reason to expect that they should apply to S/S homozygotes. In addition, one ca...